Magnesium L-Threonate


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Magnesium L-Threonate by LVLUP is the only form of magnesium proven to cross the blood brain barrier and support brain function.

120 capsules per bottle.

Magnesium L-Threonate Magtein ® is the only magnesium form proven to cross the blood brain barrier and support brain function.

The patented Magtein L-Threonate form has been shown to have the highest bioavailability, allowing it to cross the blood-brain barrier and cell membranes, which may support cognition, brain health, the nervous system, HPA axis, and mitochondrial function.

Magtein ® Magnesium L-Threonate, developed by a team of MIT scientists, is a patented form of magnesium. When developing Magtein ® Magnesium L-Threonate, the goal was to have a magnesium amino acid chelate that reached the brain efficiently. Developers decided that the amino acid L-Threonate, which is a metabolite of vitamin C, would be best for this function.

L-Threonate is a unique amino acid which appears to enhance mitochondrial function, synaptic density, and neuroplasticity on its own. It partially elevates neuronal intracellular magnesium levels which act as a second messenger. The chelation of Magtein ® Magnesium L-Threonate allows L-Threonate to enhance neuronal intracellular magnesium levels, while the magnesium elevates its levels throughout the body and the brain.

Brain Benefits

Magnesium L-Threonate appears to demonstrate a chemical attraction to the brain. In fact, there is about 5 more times L-Threonate in the brain than the rest of the body. This is a significant finding since it indicates Magnesium L-Threonate may be especially effective at elevating magnesium levels in the brain. Research has indicated that magnesium L-threonate is one of the only forms of magnesium that reaches and enters the brain efficiently at significant levels.

Researchers concluded that Magtein lead to an increase in brain magnesium levels, with an increase in both short-term synaptic facilitation and long-term potentiation, leading to improvements in learning and memory functions.

Elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of Alzheimer’s disease, and hence it might have therapeutic potential for treating Alzheimer’s disease.‍

Reduction in Anxiety

Animal studies demonstrate that Magtein helps reduce fear-related memories, and prevents fear memories from becoming over-generalized—actions that contribute directly to reductions in anxiety. While fear plays an important role in keeping us safe from real threats, persistent fearful memories from a specific traumatic occurrence can cause us to become anxious and even paralyzed into inactivity.

A study conducted at Tsinghua University found that participants reported significant reductions in anxiety, experienced less stress when performing cognitive tasks, and had greater mental clarity. Furthermore, a different paper published in the journal Pain Physician found that Magtein prevents and reverses memory deficits associated with chronic neuropathic pain.



Studies suggest taking 4 capsules 1200mg per day for maximum benefit. We suggest taking 2 capsule in the morning and 2 capsules at night to assist with sleep.

For some people however, it may be too stimulating to the brain and cognition to be taken at night; in this case 4 capsules in the morning may be best.

Unlike other forms of Magnesium, such as citrate and oxide, L-Threonate chelate does NOT cause loose bowels.


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